Modulation of Brain Dopaminergic Neurotransmission in Alcohol-preferring Rats by Alcohol and Opioids
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....................................................................................................................6 ABBREVIATIONS .........................................................................................................7 LIST OF ORIGINAL PUBLICATIONS.........................................................................8
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Effects of repeated morphine treatment on metabolism of cerebral dopamine and serotonin in alcohol-preferring AA and alcohol-avoiding ANA rats.
The alcohol-preferring AA (Alko Alcohol) rats are more rapidly sensitized to the locomotor activity-stimulating effects of small doses of morphine than the alcohol-avoiding ANA (Alko Non-Alcohol) rats. To study the involvement of dopaminergic and serotonergic transmission in this behaviour, the effects of acute morphine (1 mg/kg) challenge on the concentrations of dopamine (DA), 5-hydroxytrypta...
متن کاملImplications of endogenous opioids and dopamine in alcoholism: human and basic science studies.
We investigated the endogenous opioid system and its role in mediating the reinforcing effects of ethanol that lead to high ethanol consumption as a biochemical marker of an individual's vulnerability to excessive ethanol consumption. We performed studies using human subjects with [high risk (HR)] and without [low risk (LR)] a family history of alcoholism to supplement our studies with experime...
متن کاملIncreased brain histamine in an alcohol-preferring rat line and modulation of ethanol consumption by H(3) receptor mechanisms.
The histaminergic system is thought to regulate brain reward, but the exact mechanisms are poorly understood. This study aims to reveal the pathophysiological differences in the brain histaminergic system between selectively outbred alcohol-preferring AA and alcohol-avoiding ANA rats by using a combination of biochemical, immunohistochemical, and molecular biological methods. We also want to te...
متن کاملMorphine-induced Behavioral Sensitization in Alcohol-preferring and Alcohol-avoiding Rat Lines
Repeated use of drugs of abuse induces permanent changes in the brain that together with environmental factors can promote the development of addiction. Addiction to alcohol or drugs is a chronic disease that is characterized by a compulsion to seek and take the drug, loss of control in limiting intake, continued use despite obvious harm, and recurrent relapses. Behavioral animal models of addi...
متن کاملEthanol drinking and deprivation alter dopaminergic and serotonergic function in the nucleus accumbens of alcohol-preferring rats.
The alcohol deprivation effect is a temporary increase in the intake of, or preference for, ethanol after a period of deprivation that may result from persistent changes in key limbic regions thought to regulate alcohol drinking, such as the nucleus accumbens. The present study tested the hypothesis that chronic alcohol drinking under continuous 24-h free-choice conditions alters dopamine and s...
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تاریخ انتشار 1999